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54.128.13:541.124:542.943.7:546.262.3-31:546.92284 . . 1, . . 1,2, . . 2, . . 1 . . , , . , 2, , 65082. -mail: tlr@onu.edu.ua - . , 3, , 65082

.

. - , 2006-2012 , ( 100 ) . , - ( ), . . - , .

: , , , - .

1. - , (Au, Pt, Pd), , ( ) . , , Cu Co, - , . 1 [1-20] - , 2006-2012 33 % , . 27 % 100 ( 70 70 ).

, Cu, : CuO/ Ce0,8Sn0,2O2 [1], CuO/OMS-2 [2], Cu1Ce8Fex-O [5] CuO/CexSn1-xO2 [8]. , , , - , .. -. CuO , CuO .

. . , . . , .. , . . , 2013 . . , . . , . . , . . , . .

   

** 34 [9-13], , , [12, 13].

34- [10] ( 5-15 , 200-300 ) [12]. 34 , . , Co3O4 1,8 ppm (1,45 /3) [11] 3-10 ppm (3,75-12,5 /3) [12] 80 60 , . () , , - [14]. PdO/CoOx-SiO2 ( PdO Pd(NO3)2) 100% 40 [14].

[15] 25 PdOxH2O, , .

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2. MnO2CuO () [21]. , m = 5 , m = 25 , h = 100 %, 60 . (j = 70%) CK = CH. . 2 . , 100%- , . . , . . , . . , . . , . .

   

Zhang T.-Y., Wang S.-P., Yu, Y. Guo X.-Z., Wang S.-R., Zhang S.-M., Wu S.-H. Synthesis, characterization 1.

of CuO/Ce0.8Sn0.2O2 catalysts for low-temperature CO oxidation // Catal. Comm. 2008. Vol. 9, N 6. P. 1259-1264.

2. Liu X.-S., Jin Z.-N., Lu J.-Q., Wang X.-X., Luo M.-F. Highly active CuO/OMS-2 catalysts for low-temperature CO oxidation // Chem. Eng. J. 2010. Vol. 162. P. 151-157.

3. Huang J., Wang S.-R., Wu S.-H. Preparation, characterization, and catalytic behavior of nanostructured mesoporous CuO/ZrO2 catalysts for low-temperature CO oxidation // J. Dispers. Sci. Technol. 2010. N 31. P. 1469Luo J., Chu W., Xu H., Jiang C., Zhang T. Low-temperature CO oxidation over CuO-CeO2/SiO2 catalysts: Effect of CeO2 content and carrier porosity // J. Natur.Gas Chem. 2010. N 19. P. 355-361.

5. Ma S., Lu G., Shen Y., Guo Y., Wang Y., Guo Y. Effect of Fe doping on the catalytic performance of CuOCeO2 for low temperature CO oxidation // Catal. Sci. Technol. 2011. Vol. 1. P. 669-674.

6. Huang J., Kang Y., Yang T., Wang Y., Wang S. One-step synthesis of ternary nanostructured CuO/Ti0.8Ce0.2O2 catalysts for low temperature CO oxidation // Reac. Kinet. Mech. Cat. 2011. Vol. 104 . 149-161.

7. Mai H., Zhang D., Shi L., Yan T., Li H. Highly active Ce1xCuxO2 nanocomposite catalysts for the low temperature oxidation of CO // Appl. Surf. Sci.. 2011. N 257. . 7551-7559.

8. Cao J.-L., Wang Y., Sun G., Zhang Z.-Y. CuO/CexSn12xO2 catalysts: synthesis, characterization, and catalytic performance for low-temperature CO oxidation // Transit. Metal. Chem. 2011. Vol. 36. . 107-112.

9. Wang Y.-Z., Zhao Y.-X., Gao C.-G., Liu D.-S. Origin of the high activity and stability of Co3O4 in low-temperature CO oxidation // Catal Lett. 2008. N 125 . 134-138.

10. Tuysuz H., Comotti M., Schuth F. Ordered mesoporous Co3O4 as highly active catalyst for low temperature CO-oxidation // Chem. Commun. 2008. . 4022-4024.

11. Yu Y., Takei T., Ohashi H., He H., Zhang X., Haruta M. Pretreatments of Co3O4 at moderate temperature for CO oxidation at 80 C // J. Catal. 2009. Vol. 267, N 2. P. 121-128.

12. Xie X., Li Y., Liu Z.-Q., Haruta M., Shen W. Low-temperature oxidation of CO catalysed by Co3O4 nanorods // Nature Lett.. 2009 Vol. 458 . 746-749.

13. Wang H., Teng Y., Radhakrishnan L., Nemoto Y., Imura M., Shimakawa Y., Yamauchi Y. Mesoporous Co3O4 for low temperature CO oxidation: effect of calcination temperatures on their catalytic performance // J. Nanosci.

Nanotechnol. 2011. Vol. 11, N 5. . 3843-3850

14. Wang F., Lu G. Regulating role of cobalt oxide on deleterious chlorine ion over PdO/SiO2 for CO oxidation // J.

Phys. Chem. C. 2009. N 113. . 17070-17075.

15. Parker S.F., Refson K., Hannon A.C., Barney E.R., Robertson S.J., Albers P. Characterization of hydrous palladium oxide: implications for low-temperature carbon monoxide oxidation // J. Phys. Chem. C. 2010. N 114. . 14164-14172.

16. Luo J.-Y., Meng M., Li X., Li X.-G., Zha Y.-Q., Hu T.-D., Xie Y.-N., Zhang J. Mesoporous Co3O4CeO2 and Pd/ Co3O4CeO2 catalysts: Synthesis, characterization and mechanistic study of their catalytic properties for lowtemperature CO oxidation // J. Catal. 2008. N 254 . 310-324.

17. Slavinskaya E.M., Gulyaev R.V., Stonkus O.A., Zadesenets A.V., Plyusnin P.E., Shubin Yu.V., Korenev S.V., Ivanova A.S., Zaikovskii V.I., Danilova I.G., Boronin A.I. Low-temperature oxidation of carbon monoxide on Pd(Pt)/CeO2 catalysts prepared from complex salts // Kinet. Catal. 2011 Vol. 52, N. 2 . 282-295

18. Gulyaev R.V., Kibis L.S., Stonkus O.A., Zadesenets A.V., Plyusnin P.E., Shubin Yu.V., Korenev S.V., Ivanova A.S., Slavinskaya E.M., Zaikovskii V.I., Danilova I.G., Boronin A.I., Sobyanin V.A. Synergetic effect in PdAu/ CeO2 catalysts for the low-temperature oxidation of CO // J. Struct. Chem. 2011. Vol. 52, N 1 . 123-136.

19. Shen Y., Lu G., Guo Y., Wang Y., Guo Y., Wang L., Zhen X. An excellent support of PdFeOx catalyst for low temperature CO oxidation: CeO2 with rich (200) facets // Catal. Comm. 2012. Vol. 18 . 26-31.

20. Wu G., Guan N., Li L. Low temperature CO oxidation on CuCu2O/TiO2 catalyst prepared by photodeposition // Catal. Sci. Technol. 2011. Vol. 1. . 601-608.

21. .., .., .. , // ³. . . -.

ճ. 2004. .9, . 6-7. .33-45.

22. .., .., .. . : , 2005. 192 .

   

. . 1, . . ʳ1,2, . . 2, . . 12 . . , 쳿 㳿, . , 2, , 65082. -mail: tlr@onu.edu.ua Գ- . ,3, , 65082

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: , , , - . . , . . , . . , . . , . . T. L. Rakitskaya1, T. A. Kiose1,2, A. A. Ennan, V. Ya. Volkova1 I. I. Mechnikov Odessa National University, Department of Inorganic Chemistry and Chemical Ecology, 2, Dvoryanskaya St., Odessa, 65082. -mail: tlr@onu.edu.ua Physico-Chemical Institute of Environment and Human Protection, Preobrazhenskaya St., 3, Odessa, 65082, Ukraine

THE STATE AND PROSPECTS OF DEVELOPMENT OF LOwTEMPERATURE CATALySTS FOR CARbON MONOxIDE

OxIDATION OF RESPIRATORy PURPOSE. II. OxIDE AND

OxIDE-METAL CATALySTS Summary Original papers in the field of development of catalysts for low-temperature (not higher than 100 C) carbon monoxide oxidation published in 2006-2012 have been analyzed. Our series of articles includes the information about metal, oxide and metal-oxide (this article) as well as supported metal-complex catalysts. A comparison of the best foreign and domestic catalysts for carbon monoxide oxidation has been made. A commercial catalyst of hopcalite type has been testified and a comparison of its activation characteristics with those of the catalysts analyzed in this article has been made.

Keywords: carbon monoxide, low-temperature oxidation, oxide catalysts, oxide-metal catalysts

   

543:542.81:546.492 . . . . , , . , 2, , 65082, -mail: guzenkodom@yandex.ua

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2Hg2+ + 2HR2 + 2H2 [Hg2(RO)2]4 + 6 H+

: Hg2+ + H2O HgOH+ + H+; HgOH+ + H2 Hg(OH)2 + H+;

: 2Hg(OH)2 + 2e Hg22+ + 4-;

: HR2 + H2 2 RO3 + 3H+;

. . , 2013 . .

: Hg22+ + 2(RO)3 [Hg2(RO)2]4-, RO3-.

(I) -17-8 .

   

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C () .., .. 4--2(4--1-) -1- 6.

(II) // ³ . -. .: ճ. 2008. . 39 (820). . 16. . 136141.

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02.00.04 / . , 2005. 144 .

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10. .., .. 1,5- -2-8 -17-8 // . .: 2012. . 17. . 2 (42). . 6573.

   

. . . . , 쳿, . , 2, , 65082, , -mail: guzenkodom@yandex.ua

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. M. Guzenko Odessa National University, Department of analytical chemistry, Dvoryanskaya St., 2, Odessa, 65082, Ukraine, -mail: guzenkodom@yandex.ua

THE SORPTION ExTRACTION FEATURES OF KARMOAZONATE

MERCURy(I) COMPLEx by ANION ExCHANGER AV-17-8 SURFACE Summary The dynamic and kinetic curves were analyzed, they were obtained by karmoazonate mercury(I) complex extraction by anion exchanger AV-17-8 surface, and also calculated values of sorption process speed factor have allowed to establish the features of the adsorption layers formation on the resin surface.

Keywords: mercury(II), karmoazin, sorption, kinetics.

   

504.455:549.766.2:543.31 . . , . . , . . , . . , . . , . . , . . - . .. , 86, . , 65080, e-mail: antonovichvp@ukr.net

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, CaSO4 .

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.., .., .., .., .., .., .. - // ³ . 2006. . 11, 2. . 67-74.

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.., .., .., .., .. - . // . 2011, 1. . 87-93.

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13.

Archer E.E., White D.C., Mackison R. An Improved Titration Medium for Sulphate-ion Indicators. // Analyst. 14.

1971. V. 96, 12. P. 879-880.

.. .. 15.

// . . . . 1990, 5. . 82-84.

.., .. // . . . . . -. . . 2010, 3. . 50-52.

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266 .

18. http://corrosion.su/the_reasons_and_conditions_of_adjournment_of_inorganic_salts.php#1.1.1 Leyendekkers J.V. The chemical potentials of seawater components // Mar. Chem. 1973. V. 41, 1(2). 19.

P. 75-88.

.. , . .

20.

. .: , 1973. . 140-147.

Whitfield M. A comprehensive specific interaction model for seawater. Calculation of the osmotic coefficient // 21.

Deep-Sea Res. 1974. V. 21, 1. P. 57-67.

.., .., .. . .: , 1979. 327 .

22.

   

. . , . . , . . , . . , . . , . . , . . Գ- . .. , 86, . , 65080, e-mail: antonovichvp@ukr.net

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V. P. Antonovich, I. I. Zheltvay, N. A. Chivireva, I. V. Stoyanova, O. I. Zheltvay, A. O. Stoyanov, K. K. Tsymbalyuk A.V. bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine, Lustdorfskaya doroga, 86, Odessa, 65080, Ukraine

RATIONALE OF KUyALNIK ESTUARy FILLING ENVIRONMENTAL

SAFETy by THE bLACK SEA wATERS. CHEMICAL ASPECTS It was found that currently sulphate and calcium ions content in Kuyalnik brine close to the solubility product of CaSO4. If brine will not by dilute precipitation of gypsum may be expect in prospectstive. It is shown that the dilution of the Kuyalnik brine by seawater willreduces the concentration of calcium and sulfate ions reducing their solubility product and making it impossible the formation of calcium sulfate and precipitation of gypsum.

On the basis of established the contents of some heavy metals, polyarenes, chlorinated pesticides and polychlorinated biphenyls which were in water and sediments of the Gulf of Odessa, brine and peloids Kuyalnik estuary pronounced more pollution by priority toxicants of estuary compared with seawater. Concluded tht environmental safety of Kuyalnik estuary filling by the black Sea waters.

Keywords: Kuyalnik estuary, black sea waters, brine, peloids, gypsum, organic pollution.

   

547.891.2:615.212+262.1 . . , . . , . . , . . - . .. , . , 86, , 65080, , -mail: medchem_department@ukr.net

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1. .., .., .., .. In vivo // . 2011. 2. . 84-94.

Dziadulewicz E.K., M.C. Brown, A.R. Dunstan et al.The design of non-peptide human bradykinin b2 receptor 2.

antagonists employing the benzodiazepine peptidomimetic scaffold // bioorg. Med. Chem. Lett. 1999. Vol. 9. P. 463-468.

Wood M.R., J.J. Kim, W. Han et al. benzodiazepines as Potent and Selective bradykinin b1 Antagonists // J.

3.

Med. Chem. 2003. Vol. 46. 10. P. 1803-1806.

.., .., .., .., .., ., .., .. 3--1,2--3-1,4-2- // . . . 2012.-.46, 9. . 16-19.

.., ., .., .., .., .. 3--3-1,4--2-, // . 102273, 7D 243/14, 7D 243/26. Գ- .. . 2011 05837; . 10.05.2011; . 25.06.2013, . 12.

.. . . . 2001. 6.

. . 528.

.. // . 2007.-7. . 3-4, . 2090-2120.

.. : . . . .. 1969.

Winter C.A., E.A. Risely, G.W. Nuss Carrageenan induced oedema in hind paw of the rat as an assay for antiinflammatory drugs // Proc. Soc. Exp. biol. Med. 1962. Vol. 3. . 544-547.

10. Zeilhofer H.U., Benke D., Yevenes G.E. Chronic pain states: pharmacological strategies to restore diminished inhibitory spinal pain control // Annu.Rev.Pharmacol.Toxicol.-2012. Vol.52.-. 111-133.

11. Tjlsen A., Berge O.-G., Hunskaar S., Rosland J. H., Hole K. The formalin test: an evaluation of the method // Puin. 1992. Vol. 51. . 5-17.

12. Lattmann E., Lattmann P., Boonprakob Y., et al. In vivo evaluation of substituted 3-amino-1,4-benzodiazepines as anti-depressant, anxiolytic and anti-nociceptive agents // Arzneimittelforschung. 2009.-Vol. 59. . 2. . 61-71.

13. ., ., ., . , // . . . 2005. . 30. 12. . 21-23.

14. Wood M.R., Kim J.J., Han W., et al. benzodiazepines as potent and selective bradykinin b1 antagonists // J.Med.Chem. 2003. Vol. 46. . 1803-1806.

15. . ., . ., . . // . 2009. .7. 4. . 70-76.

15-13/343.

   

3--1,2--3-1,4--2- . . , . . , . . , . . Գ- . . . 쳿 , . , 86, , 65080, , -mail: medchem_department@ukr.net

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3--1,2-ò-3-1,4-IJϲ-2-Ͳ 1,2--3-1,4--2-, 8 (3--7--5-(2-)-1,2--3-1,4--2-) ED50=0,030 0,007 /, in vivo .

:3- 1,4-, , .

V. I. Pavlovsky, T. A. Kabanova, E. I. Khalimova, S. A. Andronati A. V. bogatsky Physico-Chemical Institute of NAS of Ukraine 86, Lustdorfskaya doroga, Odessa, 65080, Ukraine, -mail: medchem_department@ukr.net

ANALGESIC AND ANTI-INFLAMMATORy PROPERTIES OF THE

NOVEL 3 ALKOxy-1,2-DIHyDRO-3H-1,4-bENZODIAZEPIN-2ONES The analgesic activity of the series of 1,2-dihydro-3H-1,4-benzodiazepin-2-ones substituted in position 3 was studied. As a leader, it was revealed the compound 8 (3-propoxy-7-bromochloro)phenyl-1,2-dihydro-3H-1,4-benzodiazepin-2-one) with ED50 value of 0,030 0,007 mg/kg, which also has demonstrated in vivo anti-inflammatory activity in rats.

Kywords: 3-substituted 1,4-benzodiazepines, analgesia, oedema

   

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16 17 , COLO205, H23 H23/0.3, - MOLT-4 CCRFCEM, HL-60. . , 2,4,6- 16 2,4--6(5H)- 17.

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N-(4-[(2-6--4--3,4--5H-[3,2-d]-5-)] -)-l- (21, . 8) - [72]. 21 (IC50 = 46 nM, IC50 = 120 nM) 55-206 , . , , 21, 100 T. gondii [72].

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2--6--4--3,4[2,3-d]-5-) , [70].

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. T .

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Chem. 2009. Vol. 52 (15). P. 4892-4902.

   

. . 㳿, ̲ ̳ , 23, . , 65049, E-mail: valeriy_bacherikov@yahoo.com ο ղ̲ϲ.

   

V. A. Bacherikov Department of General and Clinical Pharmacology, OMI International Humanitarian University Fontans'ka road, 23A, Odessa, 65049, Ukraine E-mail: valeriy_bacherikov@yahoo.com

ANTIFOLATES FOR CANCER CHEMOTHERAPy. PART I

In the review the structure of the basic antifolate antagonists, their intracellular enzyme targets, and their mechanisms of antitumor activity were considered. Folate antimetabolites, which were discovered in the last decade and trends in finding powerful inhibitors of folic acid metabolic pathways, were discussed in details. The advantages and limitations of antifolates that can be used for the design of new drugs for antitumor chemotherapy were considered.

Keywords: antifolates, antimetabolites, antitumor chemotherapy.

   

541.49: 546.814. 131 : 547.288.3 . . 1, . . 1, . . 2, . . 2, . . 2 . . . , . , 2, , 65026.

e-mail: nshmatkova@ukr.net

(IV) 5-- ٨

SnCl4 5-- 4R- (5-brOH-Hb-4R-b) [SnCl4(5-br-2-OH-Hb-4R-b)] (R = OCH3 (I), br(II) [SnCl4(5-br-2-OH-b-4R-bH)] (R = N(CH3)2 (III)). O(C=O/C-O), N(CH=N) (I, II) , (III). - .

: , (IV), SnCl4, , .

[1, 2], , , , , , , . [3], .

(IV) [SnCl4(2-OH-bRb)] (1, 2) [SnCl4(2-OH-b-RbH)] (3), 2-OH-Hb-Rb R- : R = 4-OCH3 (1), 4-br (2), 4-N(CH3)2 (3) [1, 2]. , R (L) Sn : Cl : L = 1 : 4: 1 , O, N , : (1, 2) (3). 1-3 , , . : (2), [2]. (IV), - .

, , , , (IV) . , : , . . , . . , . . , . . , . . , 2013 . . , . . , . . , . . , . . 5-- 4R- (R = OCH3, br, N(CH3)2) .

   

(R = OCH3, br) (R = N(CH3)2) . Silufol UV-254 : = 20 : 1.

., (, %): 248 (98,5), 258 (96), 250 (95) R = OCH3, br, N(CH3)2.

[SnCl4(5-br-2-OH-Hb-4R-b)], R = OCH3 (I), br(II) [SnCl4(5-brOH-b-4R-bH)], R = N(CH3)2 (III) SnCl4 (1: 1) . 50-55 , I . II 35-40 2 . 0,5 (I) 2 (II, III) . , (I) : = 1:1 (II), 1: 2(III), 80 . 82, 92, 87 % I-III.

[5], (, (Gal) [5], [6]. () 0,001 -002 25 , [7]. () .1.

(400-4000 1) , Kbr, Shimadzu FTIR-8400S. Q-1500 D Paulik-Paulik-Erdey 20-1000 ( 10 /, 1/5 , Al2O3, 70 ).

(IV) 5--

   

(I-III) - [8]. 0,2 % , (0,2 ) ( ). . ( 40 / ) [9]. .

% .

SnCl4 5-- 4R- , ( (DNSbCl5 = 4.4) (DNSbCl5 = 26.6)), [7] Sn : : Cl = 1:1:4 (.1): [SnCl4(5-br-2-OH-Hb-4R-b)] (R = OCH3 (I), br(II) [SnCl4(5-br-2-OH-b-4R-bH)] (R = N(CH3)2 (III)). , , , (II).

I-III , . I, III , II . I (280 ) Sn br 1:1. , 280 320 (280,310) I (Dm = 23, 3 / Dm ( 4Cl-) = 23,9 %), III, (), (Dm = 16,1 / Dm ( 3Cl-) = 16,9 %). -, -. I, III ~ 65,0 (I), 66, 1% (III) 320-770 (540,680,730) (I) 325-720 (500, 680) (III), . . , . . , . . , . . , . .

   

() , , , H΅-N (I, II) HN (III), (1) (3) [2]. , (C=N) I-III .

, III : (NH) (C=O), [(NH) + (NCO)], ( ). , I, II , (NH) (C=O) [(NH) + (NCO)], C=O- [1, 2].

, I-III , (SnO) (SnN) [11, 13, 14]. III, , , - , [1, 2, 10] . I, II .

:

   

I-III - , (. 1).

, I, II 44 %, III 35 % , . , III 100 % (). II , I .

, , :

III (R = N(CH3)2) II (R = 4 br) I (R = 4-OCH3.

. . , . . , . . , . . , . . . 1. I-III.

(R) : I-III (1-3) , I, III (1), (3) . II, , (2).

, I (R = 4-OCH3) III (R = 4-N(CH3)2), (1), (3). , , , .

(IV) [16].

.

.. SnCl4 R- -(-N,N-) / .. , .. , .. , .. // ³ . ճ. 2010. . 15, .3. .77-84.

.. [-(N-4-R-- N, O) (IV)] 2.

(R = OCH3, br, N(CH3)2) / .. , .. , .. , .. . // ³ . ճ. 2013. . 18, .2 (46). .16-24.

: . ../ . 3.

.. .: . 1996. 128 .

Gunjan J. Synthesis, spectral and biological evaluation of some hydrazone Derivatives / Gunjan J., Kumawat L. // International J. Pharmaceutical Sci. Res. 2011. Vol. 2. 9. . 2408-2412.

(IV) 5-- .. / .. .: , 1965. 104 .

5.

.. / .. .: 1975. 245.

6.

Geary W.J. The use of conductivity measurements in organic solvents for the characterisation of coordination 7.

compounds / w.J. Geary // Coord. Chem. Rev. 1971. 7. P. 81-122.

Morris C.J. Carrageenan-induced paw edema in the rat and mouse / C.J. Morris // Methods Mol. biol. 2003. 8.

Vol. 225. P. 115-121.

. / . , . , 9.

.. : . .: . 1991. 268 .

.. SnCl4 -(3--2-) 4-N,N- / .. , .. , .. // . 2011. 5. . 101-105.

Sedaghat T. Some New Organotin(IV) Schiff base Adducts: Synthesis, Spectroscopic Characterization and 11.

Thermal Studies/ T. Sedaghat, M. Monajjemzadeh // J. Iran. Chem. Soc. 2011. Vol. 8, . 2. . 477-483.

. / . .: , 12.

1965. 216 .

Dutta R.L. Coordination chemistry. Chemistry of acyl, aroyl, heteroaroylhedrazones and related ligands / Dutta 13.

R.L., Hossain Md. Munkir // J. of Scientific and Ind. Research. 1985. Vol.44. .635-674.

Min Hong. Synthesis and structural characterization of organotin(IV) compounds derived from the self-assembly of hydrazone Schiff base series and various alkyltin salts/ Min Hong, Han-Dong yin, Shao-wen Chen, Da-Qi wang. // J.Organomet.Chem. 2010. Vol. 695, 5. P.653-662.

.. (II), (II), 15.

(II), : . . . : 02.00.04 / , 1984. 197 .

. . . / . ., . . .: , 1986. 363 .

   

. . 1, . . 1, . . 2, . . 2, . . 2 .. , . , 2, 65026, 쳿 , e-mail: nshmatkova@ukr.net 쳿

² (IV) 5--˲οò ̲

䳺 SnCl4 5--c 4-R- (5-br-2-OH-HbR-b) [SnCl4(5-br-2-OH-Hb-4R-b)] (R = OCH3 (I), br(II) [SnCl4(5-br-2-OH-b-4R-bH)] (R = N(CH3)2 (III)). O(C=O / C-O), N(CH=N) (I, II) , ͳ (III). (I-III) - .

: , (IV), SnCl4, , .

. . , . . , . . , . . , . . N. V. Shmatkova1, I. I. Seifullina1, A. I. Alexandrova2, I. A. Kravchenko2, A. A. Kobernik2 Odessa National University, Dvoryanskaya St., 2, Odessa, 65026 Department of general chemistry and polymers, e-mail: nshmatkova@ukr.net Department of Pharmaceutical Chemistry AbOUT NEw COMPLExES TIN (IV) wITH 5 bROM

SALICyLOyLHyDRAZONES OF SUbSTITUTED OF

bENZALDEHyDE The complexes [SnCl4(5-br-2-OH-Hb-4R-b)] (R = OCH3 (I), br(II) and [SnCl4(5-br-2-OHb-4R-bH)] (R = N(CH3)2 (III)) were obtained by interaction of SnCl4 with 5 brom-salicyloylhydrazones 4R benzaldehydes (5-br-2-OH-Hb-4R-b) in acetonitrile. In the complexes is realized bidentate O(C=O/C-O), N(CH=N) coordination of ketone (I, II) or the enol, the protonated tertiary nitrogen atom of the aldehyde fragment form of the ligand (III). It was studied the anti-inflammatory activity of (I-III) in model of aseptic carrageenan induced swelling.

Keywords: anti-inflammatory activity, tin (IV), SnCl4, hydrazones, coordination compounds.

   

542.924:541.127:546.73 . . , . . , . . .. , , . , 2, , 65026, , e-mail: truba@onu.edu.ua

(II)

(II) .

: (II), , , .

d- - [1-5]. Co(II) Mn(II), ( ) . , - [5, 6].

, (II) .

(II):

1. (SiO2) (S = 360 2/, V = 0,36, V = 0,20 3/, d = 0,5-1,0 , 4,5).

2. -300 (Si) (S = 278 2/, d = 8,710-6 , 6,0).

3. (-) ( ., , 14.5-00292540.001-2001; S = 50-65 2/, d = 0,5-1,0 , 8,5).

: CoCl2/SiO2, (II); CoCl2//SiO2 ( ); CoCl2/- CoCl2N2H4H2SO4/-,

[5-6]; Co(L1)2/Si (L1 ), [4].

[4-6].

. . , . . , . . , 2013 . . , . . , . . , o(II), , (II) o2+ + O3 + H2O = o2+ + O͕ + O2 (1)

   

(1) (2) (II) , - . , (1) , (2), .

, (1) (2) . , (1) (II) [10], , , , .

.

CoCl2/SiO2-. CoCl2/SiO2- ( 120), 3 = 3. 110 2- 3 - , (II). 3- (. 1).

(II) (2) (III) 2,

4 o3+ + 2H2O = 4o2+ + O2 + + (3)

5 .

CoCl2//SiO2-. [11], CoCl2//SiO2 (II) (5,010-75,010-4 /). (II) , (II) 5,010-6 / (. 2). , =

Co(II)

(II) ; 40-50%. ( - -) - . , .

   

, , [11], , .

(L1)2 /S i2 - . . 3 (II) .

, 200 . - . (L1)2/Si , -*- (25400 - 1) (L1), (II) [12]. (. 3) .

   

, , , .

CoCl2 / --. CoCl2/SiO2 (.1) (II), , . CoCl2/- (1,210-6 /) (2,410-4 /) (II) (. 4). , (II) , .

   

, ( 1) 0,8 / , ( 2). (II) ( 3) 2,7 / . - (III), . ( 4, 5) , 50% ( 3) 7% ( 5), , , (II) (III).

, , (III) . , (II), , , 600 . 100% (. 4, 6). , (II) , .

, (II) . : 1) , (O 2 , ) (2, 22) [7, 8] , ; 2) O͕-; 3) , , - .

˳

1. .., .., .. : . : , 2003. 298 .

.., .., .. 2.

: . : . . , 2007. 415 .

/ .. , .. , .. . // . . . . . . 1999. . 42, .4. . 3-18.

3d- / .. , .. , .. . // . . . 2013. . 83, . 2. . 305-312.

5.

(II) / .. , .. , .. . // . 2011. 2. . 118-123.

() / 6.

.. , .. , .. . // ճ, . 2013. . 4, 3. . 297-304.

Virdis A., Viola A., Goo G. A novel kinetic mechanism of aqueous-phase ozone decomposition // Ann. Chim. 7.

1995. Vol. 85, N 4. P. 633-647.

. . , . . , . . Nemes A., Fabian I., Van Eldik R. Kinetics and mechanism of the carbonate ion inhibited aqueous ozone 8.

decomposition // J. Phys. Chem. A. 2000. Vol. 104, N 34. P. 7995-8000.

Oxidation of ferrous ions by ozone in acidic solutions / T. Loegager, J. Holcman, K. Sehested et al. // Inorg.

9.

Chem. 1992. Vol. 31, N 17. P. 3523-3529.

10. Kinetics and mechanism of low-temperature ozone decomposition by Co-ions adsorbed on silica / T.L.

Rakitskaya, .. nnan, I.V. Granatyuk et al. // Catal. Today. 1999. Vol. 53, N 4. P. 715-723.

11. .. Cu(II), Co(II) Mn(II) // ³. . . -. ճ. 2009. . 14, .4. . 88-94.

12. Schiff bases containing metal complexes anchored on aerosil as catalysts of low-temperature ozone decomposition / T.L. Rakitskaya, A.A. Golub, A.A. Ennan et al. // Stud. Surf. Sci. Catal. Amsterdam: Elsevier, 2000. V. 130D. P. 3879-3884.

   

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